Please note, I am rebuilding and updating the site. Some pages may be missing and some may be on the way to be completed. I appologise for any inconvenience!

This site provides a guide to structural biology - principles of protein structure, structural bioinformatics and basic ideas of structure-based drug design. You will also find an overview of the experimental methods used in structural biology as well as an introduction to protein crystallization and X-ray crystallography. The material is primarily intended for biochemistry and biomedical students interested in structural biology and is based on a course in structural biology which I have been running at Lund University.

Please note that this site is not a comprehensive course on the subject. The full course includes lectures, tutorials and practical exercises that together constitute an essential complement to the understanding of the principles of structural biology, protein structure and function.
We cover the basic characteristics of the 20 most common amino acids, discuss relationships between the amino acid sequence and the three-dimensional structure. In addition, we discuss basics principles of sequence analysis and provide a couple of examples.
We cover the basics principles of protein structure like secondary structure elements, domains, folds and databases. We also discuss the relationships between protein amino acid sequence and the three-dimensional structure.
In this part we discuss some basics of structure-based drug design - lead discovery & lead optimization, screening small-molecule libraries and fragment-based drug design.
In the experimental part I have included some basics of protein crystallization and protein crystallography, quality of protein X-ray structures.

Structural biology services by SARomics Biostructures

X-ray crystallography services

X-ray Crystallography

protein nmr services

NMR spectroscopy

structure-based lead discovery services

Structure-based drug design

WAC fragment library screening services

Fragment library screening

Note for visitors
Please note that the site is updated few times/year, which means not continuously! I am sorry for any inconvenience. The updates may include some minor design issues, updates of links present at the site, etc. Also please note, I am not able to help you with your projects, I simply don't have enough time, I am sorry.
If you have any questions related to the web site, or any comments or suggestions, please contact me using the
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The content is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.