Structural Biology and Bioinformatics guide
This site provides a guide to structural biology - principles of protein structure, structural bioinformatics, and structure-based drug design. You will also find an overview of the experimental methods used in structural biology and an introduction to protein crystallization and X-ray crystallography. The material is primarily intended for biochemistry and biomedical students interested in structural biology. It is based on a course in structural biology that I have been running at Lund University.
Please note that this site is not a comprehensive course on the subject. The entire system includes lectures, tutorials, and practical exercises that together constitute an essential complement to the understanding of the principles of structural biology, protein structure, and function.
Please note that this site is not a comprehensive course on the subject. The entire system includes lectures, tutorials, and practical exercises that together constitute an essential complement to the understanding of the principles of structural biology, protein structure, and function.
Amino acid sequence
We cover the essential characteristics of the 20 most common amino acids and discuss relationships between the amino acid sequence and the three-dimensional structure. In addition, we discuss the basic principles of sequence analysis and provide a couple of examples.
Protein structure
We cover the basic principles of protein structure, like secondary structure elements, domains, folds, and databases. We also discuss the relationships between protein amino acid sequence and the three-dimensional structure.
Drug design
In this part, we discuss some basics of structure-based drug design - lead discovery & lead optimization, screening small-molecule libraries, and fragment-based drug design.
Experimental
In the experimental part, I have included an introduction to protein crystallization and protein crystallography and an overview of the essential criteria for the quality of protein structures.
Structural biology services by SARomics Biostructures
X-ray Crystallography
NMR spectroscopy
Structure-based drug design
Fragment library screening
Note for visitors
Please note that the site is updated a few times/year, which means it is not continuous! I am sorry for any inconvenience. The updates may include some minor design issues, updates of links present on the site, etc. Also, please note I cannot help you with your projects; I don't have enough time; I am sorry.
If you have questions related to the website or any comments or suggestions, please get in touch with me using the contact form.
The content is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Please note that the site is updated a few times/year, which means it is not continuous! I am sorry for any inconvenience. The updates may include some minor design issues, updates of links present on the site, etc. Also, please note I cannot help you with your projects; I don't have enough time; I am sorry.
If you have questions related to the website or any comments or suggestions, please get in touch with me using the contact form.
The content is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.