Please note, I am rebuilding and updating the site. Some pages may be missing, and some may be on the way to being completed. I apologize for any inconvenience!

This site provides a guide to structural biology - principles of protein structure, structural bioinformatics, and structure-based drug design. You will also find an overview of the experimental methods used in structural biology and an introduction to protein crystallization and X-ray crystallography. The material is primarily intended for biochemistry and biomedical students interested in structural biology. It is based on a course in structural biology that I have been running at Lund University.

Please note that this site is not a comprehensive course on the subject. The entire system includes lectures, tutorials, and practical exercises that together constitute an essential complement to the understanding of the principles of structural biology, protein structure, and function.

Amino acid sequence

We cover the essential characteristics of the 20 most common amino acids and discuss relationships between the amino acid sequence and the three-dimensional structure. In addition, we discuss the basic principles of sequence analysis and provide a couple of examples.

Protein structure

We cover the basic principles of protein structure, like secondary structure elements, domains, folds, and databases. We also discuss the relationships between protein amino acid sequence and the three-dimensional structure.

Drug design

In this part, we discuss some basics of structure-based drug design - lead discovery & lead optimization, screening small-molecule libraries, and fragment-based drug design.

Experimental

In the experimental part, I have included an introduction to protein crystallization and protein crystallography and an overview of the essential criteria for the quality of protein structures.

Structural biology services by SARomics Biostructures

X-ray crystallography services

X-ray Crystallography

protein nmr services

NMR spectroscopy

structure-based lead discovery services

Structure-based drug design

WAC fragment library screening services

Fragment library screening

Note for visitors
Please note that the site is updated a few times/year, which means it is not continuous! I am sorry for any inconvenience. The updates may include some minor design issues, updates of links present on the site, etc. Also, please note I cannot help you with your projects; I don't have enough time; I am sorry.
If you have questions related to the website or any comments or suggestions, please get in touch with me using the
contact form.

Creative Commons License
The content is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.